The resident orchestra, the Düsseldorfer Symphoniker, play both opera and symphonic repertoire.

After the 1875 construction of what became the Düsseldorf Opernhaus, a strong connection between the two cities' opera houses existed from 1887 to 1920, and was not re-established until 1955 with the creation of the Deutsche Oper am Rhein.

The current general manager is Christoph Meyer; the chief conductor is Axel Kober.

The first opera performance in the newly renovated theater was La traviata, conducted by the American John Fiore.

[1] Two singers of the opera, member Oleg Bryjak and guest artist Maria Radner, were killed in the Germanwings Flight 9525 disaster.