[4] In December 2018, he was bought by the Royal Challengers Bangalore in the player auction for the 2019 Indian Premier League.
[13] In February 2024, he was added to India's Test squad for their series against England as a replacement of KL Rahul.
Padikkal won the Emerging Player Award for the 2020 Indian Premier League (IPL), playing for Royal Challengers Bangalore.
[19] In February 2022, he was bought by the Rajasthan Royals in the auction for the 2022 Indian Premier League tournament.
[20] In March 2022, Padikkal scored his maiden first-class century, with 178 runs in the 2021–22 Ranji Trophy match against Puducherry.
[23] Royal Challengers Bengaluru have bought Devdutt Padikkal at his base price of INR 2 crore in the 2025 Indian Premier League auction.