Veteran Inhuman Alisha Whitley tracks down some old friends from Afterlife, Shane and Lori Henson, with the aim to recruit them into the Secret Warriors.
Daisy Johnson and Alphonso "Mack" Mackenzie pursue Lash, while Phil Coulson alerts Rosalind Price, who sends an Advanced Threat Containment Unit (ATCU) team to help, but they are unable to apprehend the Inhuman.
Coulson and Andrew Garner are stunned when May arrives at the Playground to voice her concerns about Hunter, believing he is too personally involved in his mission, fixated on avenging Ward's attempted murder of Bobbi Morse.
Coulson convinces Price to let Daisy and Mack join the ATCU team taking Frye into custody, so they can see what the organization are doing with the Inhumans they apprehend.
May joins the fight, at which point Ward reveals he has sent Hydra agents, including Werner von Strucker, to kill Andrew at a gas station, offering to call them off if May and Hunter surrender.
Hunter refuses and chases Ward, managing to shoot him in the shoulder before he escapes with Kebo, and May contacts Coulson to warn him that Andrew is in danger.
In October 2015, Marvel announced that the fourth episode of the season would be titled "Devils You Know", to be written by Paul Zbyszewski, with Ron Underwood directing.
[1] In October 2015, Marvel revealed that main cast members Clark Gregg, Ming-Na Wen, Brett Dalton, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Nick Blood, Adrianne Palicki, Henry Simmons, and Luke Mitchell would star as Phil Coulson, Melinda May, Grant Ward, Daisy Johnson, Leo Fitz, Jemma Simmons, Lance Hunter, Bobbi Morse, Alphonso "Mack" Mackenzie, and Lincoln Campbell, respectively.
[1] It was also revealed that the guest cast for the episode would include Blair Underwood as Andrew Garner, Constance Zimmer as Rosalind Price, Matthew Willig as Lash, Daz Crawford as Kebo, Andrew Howard as Luther Banks, Spencer Treat Clark as Werner von Strucker, Alicia Vela-Bailey as Alisha Whitley, Alexi Wasser as Lori, Nick Eversman as Shane and Chad Lindberg as Dwight Frye.