In 2003, she began performing with men, starting with the final scene in The Devinn Lane Show 5: Save The Best For Last.

[3] Over the next two years she performed scenes with men in Kink, Lovestruck, Space Nuts, Improper Conduct, Wicked Sex Party 6, Beautiful, Stiletto, Tuff Chick, two Road Trixx movies (which she also directed), and Lovers Lane.

As of 2005, she went on indefinite hiatus from on-screen work, focusing on directing for the production company Shane's World.

In October 2008, Lane filed a copyright infringement lawsuit against Digital Playground, Vivid Entertainment Group, and Moniker Online Services among other entities, alleging that they profited from domain names similar to her performer name and did not compensate her.

[4][5] In February 2009, she dismissed her claims against most of the companies, leaving only Privacy Protect and Pixel named in the suit.