The winner of several AVN Awards, she has spent most of her career as a contract performer with major producer Vivid Entertainment, and is known for her roles in acclaimed adult films such as The New Devil in Miss Jones.

A native of upstate New York, she entered the adult film industry in 2000, after working as a dancer at the Manhattan strip club, Scores.

Samson's move into the adult film business began in 2000, after she wrote a letter to Italian porn actor and director Rocco Siffredi, asking to work with him.

The Girls were featured alongside mainstream actors, such as Daniel Day-Lewis and Julianne Moore, in a double-page photograph taken at Elton John's home on the French Riviera.

[20] Later in the year, she was featured alongside Jenna Jameson in Vivid's high-budget remake of the classic adult film The Devil in Miss Jones.

[26][27][28][29] Michael Lucas' 2006 gay-porn remake of La Dolce Vita featured a cameo appearance by Samson,[30][31] which in 2007 won her the GayVN Award for "Best Non-Sexual Performance".

A long-time Wagner fan, Samson said, "I think I'm in a unique position to discuss the sensual aspects of the 'Tristan and Isolde' characters and of opera in general".

[40] In April 2008, Samson became a political correspondent on Fox News's late-night talk show Red Eye w/ Greg Gutfeld.

[41] She had made several previous appearances on the show, and in 2007 had endorsed New York Republican mayor Rudy Giuliani's presidential candidacy.

[42][43] In September 2008 her debut album, Possession, was released,[44] and her first single, a title track co-written by Samson during the breakup of her marriage.

[3] A 2006 article in The New York Times reported that she earns from $20,000 to over $100,000 per film, depending on sales, with each one taking from three days to two weeks to make.

[5] An Adult Video News article written in February 2006 stated that Samson had five years left on her contract with Vivid.

[9] She formed the company, Savanna Samson Wines, and asked Italian winemaker and consultant Roberto Cipresso to help find a blend of grapes local to Tuscany that would produce her ideal flavor.

Its label played on Samson's notoriety as a porn star, featuring a side view of her wearing only a see-through gown and high heels.