The film marks the debut of Akkineni Nageswara Rao, who played a minor role as one of the ten school children in a song sequence, and also that of the writer Chakrapani.

The lecherous Ananda Rao informs Mohan's father that his son was seeing the daughter of a harlot Sridevi.

Dharmapathni also marked the debut of one of Telugu cinema's later day doyen Akkineni Nageswara Rao in a small role.

Nageswara Rao's brother Ramabrahmam took him to Kolhapur hoping he would get the male lead's childhood character.

Since Nageswara Rao was too old for the role, Pullayya signed him as one of the ten school children for the song sequence "Anandamayega mana Mohanudu".

But since they were too grammatical, Chakrapani, then already popular for his Telugu translations of Bengali writer Sarat Chandra Chatterjee's works, was hired.