Didolodontidae is a possibly paraphyletic family of "condylarth" mammals known from the Paleogene of South America,[2][3] with most specimens known from Argentina.

They were generally small-medium in body size, and had a bunodont dentition.

A close relationship with litopterns has been suggested by some studies.

[4] They range in age from the early Paleocene (Selandian/Peligran) to late Eocene (Priabonian/Mustersan).

The attribution of Salladolodus deuterotheroides from the Late Oligocene of Bolivia to the family is doubtful.