The resulting amine is then combined with acetic anhydride to produce the final product DEAM, achieving a total yield of 77% acetylation.

Diethyl acetamidomalonate is a white powdery substance characterized by low water solubility, but possessing good solvency in lower alcohols and chloroform.

[3][4] The oxidation-sensitive amino acid rac-tryptophan can be synthesized using diethyl acetamidomalonate and gramine, or through its quaternary ammonium compound which can be obtained with methyl iodide or dimethyl sulfate, yielding results of > 90%.

The resulting bonds of alkyne residues that are attached to the polymer chain in the acquired polylactide copolymer can then be made to undergo a cycloaddition with functional organic azides in order to create 1,2,3-triazoles.

[10] For the production of Fingolimod—an immunosuppressant used to treat multiple sclerosis, numerous synthetic routes have been developed utilizing diethyl acetamidomalonate as the principal component.