A differential screw is a mechanism used for making small, precise adjustments to the spacing between two objects (such as in focusing a microscope,[2] moving the anvils of a micrometer,[3][4] or positioning optics[5]).
Flamsteed’s Preface to the Historia Coelestis Britannica: "Richard Towneley ... carried forward and completed his instrument (the micrometer) and made it perform with one screw, what on Gascoigne’s instrument had required two.” [9] A drawing by Robert Hooke in 1667 clearly shows Towneley’s Micrometer with the single screw with two different pitch threads on it.
With this differential screw, one thread was half the pitch of the other, Towneley was able to keep the micrometer's indicating pointers centered in the field of view as they opened and closed.
Another arrangement holds the two "nuts" co-axially in a single fixture and has two separate screws with slightly different pitches (distance from the crest of one thread to the next) entering from opposite ends.
[1] For single start threads, each turn changes the distance between the nuts by the effective pitch, Peff.