Static light scattering or SLS and its many types are well outlined in literature[citation needed] and is the base principal for DSLS but varies specifically in that the difference (before and after) is the focus of this measurement.
Solution conditions can be varied across samples of a specific protein in a screening scenario and the system can be kept at either a static temperature or be ramped up, or in some cases down.
There are other technologies or techniques using similar concepts such as DLS (dynamic light scattering) to obtain this information with the help of fluorophores and the use of lasers for excitation however the primary focus in this arena is on particle sizing.
Many proteins are discovered on an annual basis and in the field of drug discovery it is very important characterize the structure of a novel peptides as well as the best conditions to keep them in solution.
Because of this staggering number of potential therapeutics churning out of this research sector today there is a strong need for instrumentation to best capture this data and to date there are a few solutions that are DSLS focused.