Dimethylstilbestrol (DMS) is a nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol which was never marketed.

[1][2][3][4][5]: 213  It is a so-called "weak", "impeded", or "short-acting" estrogen similarly to estriol and meso-butoestrol.

[6][7][8][9] The affinity of DMS for the ER was reported as about 10% of that of estradiol.

[10] The endometrial proliferation dose of DMS in women is 20 mg.[5]: 212–213  A single 12 mg intramuscular injection of DMS has a duration of approximately 12 days in humans.

[5] This drug article relating to the genito-urinary system is a stub.