Dimitrios was from a prominent Greek American family and his father was the well-known author and doctor Michael D. Kalopothakis.

The book attracted the attention of Eleftherios Venizelos who appointed Dimitrios Director of the Press Bureau to the Ministry of Foreign Affairs for over eleven years.

His father founded the Christian magazine Asteri tis Anatolis (Star of the East).

Dimitrios traveled back and forth to Greece helping his father start a newspaper in Volos in 1885 entitled Simaia (Flag).

He traveled to Germany and obtained a doctorate degree from the University of Berlin in 1893 while also training in the field of international affairs and diplomacy.

The main purpose of the organization was to liberate Thessaloniki and northern Greece from the Ottoman Empire.

Dimitrios participated in combatting Bulgarian influence in Macedonia by providing guns, money, and equipment to the Greek fighters.

By the end of World War I, he played a vital role at the Paris Peace Conference.

Eleftherios Venizelos was extremely impressed by his work that he appointed the journalist diplomat Director of the Press Bureau, to the Ministry of Foreign Affairs also directing the Thessaloniki branch.