The Roman Catholic Diocese of Keimoes–Upington (Latin: Dioecesis Keimoesana–Upingtonensis) is a South African diocese located around the towns of Keimoes and Upington (ZF Mgcawu District Municipality, Northern Cape) in the ecclesiastical province of Bloemfontein.

The Cathedral is the Cathedral of the Immaculate Conception in Pella (Namakwa District Municipality).

The Co-Cathedral is the Co-Cathedral of St. Augustine in Upington.

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