Diopside is also found in a variety of metamorphic rocks, such as in contact metamorphosed skarns developed from high silica dolomites.

Chrome diopside ((Ca,Na,Mg,Fe,Cr)2(Si,Al)2O6) is a common constituent of peridotite xenoliths, and dispersed grains are found near kimberlite pipes, and as such are a prospecting indicator for diamonds.

[10] Green diopside crystals included within a white feldspar matrix are also sold as gemstones, usually as beads or cabochons.

[11] Diopside derives its name from the Greek dis, "twice", and òpsè, "face" in reference to the two ways of orienting the vertical prism.

A diopside based glass-ceramic named 'silceram' was produced by scientists from Imperial College, UK during the 1980s from blast furnace slag and other waste products.

Similarly, diopside based ceramics and glass-ceramics have potential applications in the field of biomaterials, nuclear waste immobilization and sealing materials in solid oxide fuel cells.