The museum and its Discovery Woods accessible outdoor nature playscape and 550 sq ft (51 m2) tree house blend the best of STEAM (Science, Technology, Engineering, Art and Math) learning on a beautiful 4.5 acres (1.8 ha) campus abutting 180 acres (73 ha) of conservation land in Acton, about 20 mi (32 km) west of Boston.

Discovery Woods, opened on the campus in July 2016, abuts 183 acres (74 ha) of conservation land on Great Hill used for visitor programs.

In combination with the museum’s Discovery Woods outdoor nature playscape and treehouse, the entire campus is accessible.

The former Science Discovery Museum was housed in a purpose-built postmodern building[7] designed by E. Verner Johnson & Associates.

It is this structure that was completely renovated and expanded in 2018; the original Children's Discovery Museum building remains on campus but is used for office space and is closed to the public.