"Disease" is the first single released from American rock band Matchbox Twenty's third album, More Than You Think You Are.

The track was co-written by Matchbox Twenty lead singer Rob Thomas and Rolling Stones frontman Mick Jagger.

"Disease" was one of two songs written by Thomas and presented to Jagger while he was producing his solo album Goddess in the Doorway, alongside "Visions of Paradise".

"[1] The video, directed by Phil Harder, starts with a man turning on his colorful boomboxing, then roller skating over a wide section of New York City, amid images of the band illuminated on moving billboards.

At the end of the song, the roller skater shuts off his beat box and then proceeds up some stairs, presumably to his home.