She has appeared in films in Tamil, notably in the commercial success, Thamizh Padam (2010), and in Telugu, Kannada and Hindi.

In comments published in a 2011 article in The New Indian Express, Pandey shared that her father was a gazette officer with the education department, and that her mother worked with Hindustan Copper.

Despite choosing biology with mathematics in class 12, Disha decided to pursue arts to be able to complete her degree more easily.

[2][3][4] She acted in Mayanginen Thayanginen (2012), a Tamil flick opposite Nitin Sathya and Moksha (2013), a Telugu horror film, directed by Srikanth Vemulapalli.

In Mayanginen Thayanginen she played the character of a very homely girl — a customer care executive employed with a call taxi company.