Arguably, its most visible publications to date are 50 Things You're Not Supposed to Know and the Everything You Know About [subject] Is Wrong series, both by the company's editor-at-large Russ Kick.

[2] In 1996, Tele-Communications Inc. (now Comcast) funded a Hollywood-based[citation needed] Internet initiative responsible for online projects like the Getty Museum and an Internet-based political humor soap opera entitled Candidate 96.

[citation needed] The initiative launched its own interactive website, featuring the tag line; "everything you know is wrong".

In 2000, Disinfo organized DisinfoCon, a 12-hour event featuring Richard Metzger, rock musician Marilyn Manson, underground filmmaker Kenneth Anger, painter Joe Coleman, Douglas Rushkoff, Mark Pesce, Grant Morrison, Robert Anton Wilson, Todd Brendan Fahey and others.

In 2002, the company produced a four-episode documentary series called Disinformation (also alternatively titled as Disinfo Nation).