An alternate version of Hades appeared in the latter half of Once Upon a Time's fifth season starting with "Souls of the Departed" portrayed by Greg Germann.

In the episode "Labor of Love" alternate versions of Hercules and Megara were both portrayed by Jonathan Whitesell and Kacey Rohl.

It is a first–person adventure/puzzle game and a spinoff to Hercules in which the player assumes the role of a rookie hero undergoing various adventures based upon elements of Greek mythology not directly explored in the main film while being recurrently antagonized by Hades and Pain and Panic.

The characters of the film appear in the Kingdom Hearts video game series in the recurring in-game world of "Olympus Coliseum".

It is the most represented Disney franchise appearing in nearly every entry in the series bar Kingdom Hearts: Dream Drop Distance.

In Kingdom Hearts II, the Underworld can be explored and includes new characters like Megara, Pain and Panic, Pegasus, and Hydra.

Hades, Pain, and Panic (the latter two both portrayed by women) especially packed a humorous punch, infusing relevant pop-culture references into the script.

They often changed to keep up with current trends, much like Genie's jokes in Aladdin: A Musical Spectacular, a former show at Disney California Adventure.

[8] The cast will include Jelani Alladin (Hercules), Roger Bart (Hades), Jeff Hiller (Panic), James Monroe Iglehart (Phil), Ramona Keller (Thalia), Tamika Lawrence (Calliope), Krysta Rodriguez (Meg), and Rema Webb (Terpsichore).