Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action.

It is available as tablets on prescription only.

It is commonly used to treat various conditions, including myasthenia gravis and underactive bladder.

[2] Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.

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