After studying he spent his spare time to read and write many articles for the Tjahaja Hindia magazine.
From Germany, Adinegoro visited the Balkan countries, Southeast Europe, Turkey, Greece, Italy, Egypt, Abyssinia and India that gave him ideas to write.
Adinegoro's travel journal first appeared in Pandji Pustaka magazine and was published as a book, A Journey to the West.
His writing was readable, filled with knowledge, popular and easy to understand by readers who didn't have high education.
[7] Under Adinegoro's leadership, Pewarta Deli had many improvement and changes, not only in terms of layout and news reporting, but also in the choice of articles.
On 25 August 1932, Adinegoro married Alidar binti Djamal, a woman from Sulit Air, Solok, West Sumatra, his friend from STOVIA, with whom he had five children.
Although living a life of scarcity, Adinegoro had a high commitment as a reporter and writer who produced two literary works: Darah Muda and Asmara Jaya.
In Pewarta Deli editorial, Adinegoro expressed his thoughts about colonialism, the struggle for independence, nationalism and education.
Because of his brilliance in choosing words, Adinegoro always managed to escape the legal traps made by the Dutch colonial government in Persbreidel-Ordonantie.
He encouraged the people of Sumatera to carry out the President's command: to take over the government from the Japanese and declare Proclamation of Independence along with the local leaders.
Besides running the Kedaoelatan Rakjat newspaper, Adinegoro also established Sumatra branch of Antara newswire service.