Djedkhonsuefankh was a High Priest of Amun in Thebes believed to have been in office from 1046–1045 BC.
It is often assumed that he was a son of Pinedjem I who succeeded his brother Masaherta during a time of great turmoil in the city of Thebes.
Jürgen von Beckerath has even suggested that it is possible that he died a violent death, accounting for his very short reign.
The title of High Priest on his coffin would then be given posthumously by his son "[...]re" Niwiński also points out that theophoric names as Djedkhonsuefankh mainly appear very late in the 21st Dynasty.
Djedkhonsuefankh's wife is likely to have been Djedmutesankh, a Singer of Amun, who was buried in Tomb MMA60 in Deir el-Bahari.