Souhra Ali Mohamed, who had previously participated in the 2012 Summer Olympics competed in the women's 1500 metres event.

The Djiboutian team at the 2020 Games featured two track and field athletes, a judoka and a swimmer.

[7] Sprinter Souhra Ali Mohamed, who had previously represented Djibouti at the 2012 Summer Olympics in London, made her second appearance at the games in the women's 1500 metres event.

[6] Souleiman had been due to compete in the sixth heat of the men's 800 metres taking place on 31 July, however he did not start the race.

During semifinals, Souleiman participated in the first heat, where he ran his event but was unable to finish the race .

The heat's leaders were Great Britain's Jake Wightman (3 minutes 33.48 seconds), United States's Cole Hocker (3 minutes 33.87 seconds) and eventual silver medalist Timothy Cheruiyot of Kenya.

[15] At 26 years old, Souhra Ali Mohamed was making her second appearance at the Summer Olympics.

her heat was led by Kenya's Faith Kipyegon who went on to win the gold medal in the finals and achieve an Olympic record with a time of 3 minutes and 53.11 seconds.

Aden-Alexandre Houssein accepted a continental berth from Africa as the nation's top-ranked judoka outside of direct qualifying position in the IJF World Ranking List of 28 June 2021.

[9] His brother, Anass Houssein competed in the men's half-lightweight for Djibouti at the 2016 Summer Olympics.

Houssein competed in the men's lightweight competition, held on 26 July, and received a bye through the first round.