The film is a variation on Robert Louis Stevenson's 1886 novella Strange Case of Dr Jekyll and Mr Hyde and stars Udo Kier, Marina Pierro, Patrick Magee, Howard Vernon, and Gérard Zalcberg.

When Henry goes to see if he can revive the coachman, an unknown man appears in the Jekyll household and begins to attack the guests.

She watches as Henry plunges into a bath of unknown chemicals and transforms into his alter ego: Edward Hyde.

Fanny follows Hyde through the house as he brutalizes the other guests, including forcing Mrs. Osborne to play the piano until her fingers are numb and killing the Carews with arrows.

Borowczyk wanted to call his film Le cas étrange de Dr.Jekyll et Miss Osbourne but his distributors UGC insisted it be released under the title Docteur Jekyll et les femmes.

[1] Docteur Jekyll et les femmes never opened commercially in the United States, and in Britain, it played at one cinema for one week.

Arrow also restored Borowczyk's preferred title The Strange Case of Dr Jekyll and Miss Osbourne.