Her 2023 single "What It Is (Block Boy)", featuring Kodak Black, marked her first entry on the Billboard Hot 100 and was certified platinum by the Recording Industry Association of America (RIAA).

Doechii's third mixtape, Alligator Bites Never Heal (2024), was met with critical acclaim and won Best Rap Album at the 67th Annual Grammy Awards; this made her the third woman to win in the category.

Doechii has made guest appearances on other musicians' releases, including "Anxiety" by Sleepy Hallow, "Balloon" by Tyler, the Creator, and "I'm His, He's Mine" by Katy Perry.

[5] Doechii attended Howard W. Blake High School and grew up performing ballet, tap dancing, acting, cheerleading, doing gymnastics, and playing soccer.

[11] "Yucky Blucky Fruitcake", a single from the EP released in September 2020, was inspired by her reading The Artist's Way and went viral on TikTok in 2021, earning her attention from record labels.

[12][13][10] In March 2022, she was signed to Capitol Records by Chris Turner and Top Dawg Entertainment, making her the first female rapper on the latter label.

[14][15] That same month, she released "Persuasive", her first single published through Top Dawg,[16] and appeared as a featured artist on David Guetta and Afrojack's song "Trampoline", alongside Missy Elliott and Bia.

[23][24][25] Pitchfork called it "her most ambitious and musically diverse release" filled with "playful and melodic sides without skimping on hard-hitting hip-hop".

Doechii appeared as a guest judge on a January 2025 episode of RuPaul's Drag Race season 17, with her song "Alter Ego" featured in a lip-sync competition.

[10][34][35] She has also expressed admiration for artists including Trick Daddy, Grace Jones, Paramore, Madonna, KRS-One, and MF Doom.