Production for the album was done by The Neptunes, The Trak Starz, Dre & Vidal, DJ Toomp, The Runners and Polow da Don, and features guest contributions from rappers Young Jeezy, Field Mob, Beanie Sigel, Pimp C and C-Murder and R&B singers Pharrell, Mary J. Blige, R. Kelly and Bobby Valentino.

Release Therapy received generally mixed reviews from music critics divided over Ludacris' foray into more conscious rap territory while still being able to deliver mainstream hip-hop content.

"[3] Robert Christgau gave the album a two-star honorable mention, indicating a "likable effort that consumers attuned to its overriding aesthetic or individual vision may well enjoy.

"[4] Brett Johnson of XXL gave praise to Ludacris for having a balanced track list containing his trademark humorous party jams and newfound sociopolitical commentary cuts, calling it "a solid album short on obvious club bangers but long on the more worldly perspective of a rap veteran.

"[11] Marisa Brown of AllMusic commended the 'Therapy' half of the album but felt that the 'Release' portion of the tracks was missing some humor, saying that "the witty rhymes that made Chicken-n-Beer so great are in short supply.

"[2] Entertainment Weekly's Michael Endelman was the opposite in his critique of the record, praising Ludacris for maintaining his lyrical humor and dexterity on tracks like "Ultimate Satisfaction" and "Grew Up a Screw Up", but was less positive towards his attempts at depth on "Runaway Love" and "Do Your Time", saying that "[T]hough well-intentioned, they come across as trite.

"[5] Pitchfork writer Tom Breihan felt the album was overhyped due to various interviews of Ludacris calling it a classic, resulting in a project with a weak track list structure, diluted punchlines and poor attempts at conscious rap.