Dog appeasing pheromone

[2] Synthetic DAP analogues have been developed which may support dogs during some, but not all, stressful situations.

[8][9] Synthetic DAP can be effective at reducing stress-related behaviours in a number of contexts[10] including puppies enrolled in socialization classes.

[11] A double-blind, placebo-controlled study found that newly adopted puppies aged 6 to 10 weeks cried less when exposed to synthetic DAP, but only in gun-dog breeds.

[2] Synthetic DAP is ineffective for dogs housed in long-term kenneling facilities[10] and does not reduce soiling behaviour in newly adopted puppies.

[12] In 2014, a critical review of studies on the use of synthetic DAP in veterinary hospital wards concluded that there was "little or no robust evidence" of it being effective in this environment.