[10][11] In 2001, the company opened two additional distribution centers in Savannah, Georgia and Briar Creek, Pennsylvania.

[12][13] In 2003, Dollar Tree acquired Salt Lake City, Utah-based Greenbacks, Inc., and opened a new distribution center in Marietta, Oklahoma.

[16][17] In 2006, Dollar Tree celebrated its 20th year of retailing at a $1.00 price point, opened its 3,000th store, and acquired 138 DEAL$ stores, previously owned by SUPERVALU INC.[18] In 2007, Dollar Tree expanded its Briar Creek Distribution Center and crossed the $4 billion sales threshold.

By the close of 2009, the company opened a store in Washington, D.C., and purchased a new distribution center in San Bernardino, California.

DollarTree.com sells Dollar Tree merchandise in larger quantities to individuals, small businesses, and organizations.

In 2011, Dollar Tree achieved total sales of $6.63 billion, opened 278 new stores, and completed a 400,000 square feet (37,000 m2) expansion of its distribution center in Savannah, Georgia.

[23] In June 2015, the firm agreed to sell 330 stores to private equity company Sycamore Partners as part of the approval process for its $8.5 billion takeover of Family Dollar.

[27] Dollar Tree has opened and operated nearly 50 locations by the end of 2020, primarily in small towns with populations of just a few thousand people.

[28] On September 28, 2021, CEO Michael Witynski, citing increased shipping and labor costs squeezing profit margins, announced that some prices will be rising above $1, possibly to as much as $1.50.

[30] On March 13, 2024, Dollar Tree reported a loss of $1.71 billion for latest quarter and announced the closure of near 1,000 stores.

[34] In December 2024, Dollar Tree announced that its Board of Directors appointed Interim CEO Michael C. Creedon, Jr. as permanent Chief Executive Officer.

[36] It claims to be able to achieve this because their buyers "work extremely hard to find the best bargains out there,” and it has "great control over the tremendous buying power at the dollar price-point.”[37] Its prices are primarily designed to attract financially disadvantaged customers, but it has also become popular within immigrant communities.

[38][39][40] The deal came in the month following activist investor and major shareholder[41] Carl Icahn's demand that Family Dollar be promptly put up for sale.

[49][50] At the time of the acquisition, Dollar Giant had about 85 retail outlets in the provinces of British Columbia, Alberta, Saskatchewan and Ontario.

[51] Approximately 30 of its retail locations are in British Columbia, making it the second largest dollar store chain in that province.

[52] Dollar Tree Canada's merchandising team is located in Mississauga, Ontario, while its corporate office remains in Burnaby in Greater Vancouver.