Domenico Agostini (31 May 1825 — 31 December 1891) was an Italian Roman Catholic Cardinal and Patriarch of Venice.

He took a doctorate of philosophy and law, but he left the clerical state to join the citizen militia during the war with Austria in the period 1848–1850.

He was ordained priest on 26 January 1851 in Venice and incardinated in the diocese of Treviso.

Agostini was created cardinal priest in the consistory of 27 March 1882 by Pope Leo XIII with the title of Sant'Eusebio.

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