As well as reading news, Byrne interviewed many celebrities for the breakfast show including Tom Cruise, Gwyneth Paltrow, Ben Stiller, Alan Sugar, David Schwimmer, Uma Thurman, Goldie Lookin' Chain, Reese Witherspoon, William Shatner, Al Gore, Dion Dublin, Richard E. Grant, Daniel Craig, Bruce Willis, Bono, Adam Clayton, Daniel Radcliffe, Robert Downey Jr., Jennifer Aniston, Jedward, Leonardo DiCaprio, Matt Damon, Jennifer Lopez, Elton John and Cameron Diaz.

In December 2011 Dominic Byrne championed the song Dominick the Donkey by the late Italian-American singer Lou Monte on The Chris Moyles Show, helping it achieve a peak chart position of number 3 on the UK Top 40 during Christmas 2011.

He provided the voice of an alien called Zorst in the CBeebies show Space Pirates,[4] and as Captain Emergency on Peppa Pig.

[6] Byrne owns a company called Open Mouth Productions, through which he provides vocal training for both corporate and private individuals.

[7] In a video recorded for Radio X's YouTube channel, Byrne played guitar with Stereophonics alongside Chris Moyles on the drums.

[8] In January 2023, Byrne released a song called Holy Water (featuring Abigail Dhese-Biggs on vocals) which he had written at least two decades prior.