[1] Initial diplomatic relations between the two nations were unsteady due to several coup d'état, civil wars and foreign interventions; occurring in the Dominican Republic.

In April 1965, the United States government under President Lyndon B. Johnson feared that the Dominican Republic would turn into a 'second Cuba' after the assassination of Trujillo and sent in the marines to occupy the country.

Soon after the election of President Joaquín Balaguer, American marines pulled out of the country in July 1966 and diplomatic relations between Mexico and the Dominican Republic returned to normal.

Both nations are an active members of multinational organizations and have committed themselves to strengthen the legal framework in areas of common interest such as commercial; social development; and the recovery and restitution of cultural property.

[7] Several Mexican multinational companies such as América Móvil, Cemex, Jumex and Sigma Alimentos operate in the Dominican Republic.