With the cancellation of the 2021 Pan American Qualification Tournament in Buenos Aires, all of them, led by Rio 2016 Olympian Leonel de los Santos (men's lightweight), finished among the top five of their respective weight divisions to secure their places on the Dominican Republic squad based on the IOC's Boxing Task Force Rankings for the Americas.

[8] Dominican Republic entered one diver into the Olympic competition for the first time since Los Angeles 1984, by attaining a top 18 finish and securing the last of seven available berths in the men's springboard at the 2021 FINA Diving World Cup in Tokyo, Japan.

Dominican Republic entered one equestrian rider into the Olympic competition by finishing among the top fifteen and securing the last of four available slots in the individual jumping at the 2019 Pan American Games in Lima, Peru.

[11] Dominican Republic qualified one boat in the men's single sculls for the Games by finishing fifth in the B-final and securing the last of five berths available at the 2021 FISA Americas Olympic Qualification Regatta in Rio de Janeiro, Brazil, marking the country's debut in the sport.

Meanwhile, Rio 2016 Olympian Luis García and rookie Zacarías Bonnat topped the field of weightlifters vying for qualification from the Americas in the men's 61 and 81 kg category, respectively, based on the IWF Absolute Continental Rankings.