Located on the edge of Gastown (207 West Hastings St), it was Vancouver's first steel-framed high-rise.

[4] Its architect was John S. Helyer,[5] who is said to have died after falling off the staircase in the front of the building, though this is an urban legend.

The building's current tenants include a film production company (Haddock), a law firm, clothing designers, record labels, antiquarian booksellers, Kokoro Dance, professional web developers, marketing agency, Bowery Creative, the office of the Green Party of Vancouver, a dentist, non-profit organizations such as Living Oceans Society and Fair Trade Vancouver and a Lebanese restaurant, Nuba.

The Dominion Building, as well as other elements of Victory Square, were filmed for scenes in an abandoned city in Battlestar Galactica.

[citation needed] In The NeverEnding Story (film), Building is seen in closing scene, when Bastian is flying with Falkor, to get some revenge over the kids.