She holds a postgraduate degree in Banking and Monetary Economics from the University of Sorbonne.

[2][3] Senequier began her career as insurance commissioner for the French Ministry of Finance, where she worked from 1975 until 1980.

She worked in reinsurance, international development, and private equity at GAN, a subsidiary of Groupama from 1980 to 1996.

[2][16] In October 2013, she was named in the Bloomberg Top 50 Most Influential People in the world in Money Managers category.

[17] She is a concert-standard pianist who enjoys opera, sometimes travelling to Venice and Salzburg to hear it.