She was the daughter of Flavius Liberalis, a humble quaestor’s clerk from Ferentium (modern Ferento), a country town in Italy.

[5][7] Regardless of the exact circumstances surrounding this relationship, the context suggests that Domitilla filled some servile role within the estate of Statilius.

[6] In a case established by her father, Domitilla's status was raised to that of a freeborn Roman citizen through the approval of the arbiters.

[8] After her death she is often identified with the figure Diva Domitilla, a deified woman of the Flavian dynasty; though there is a debate over whether this title belongs to her or to her daughter.

[2] Evidence for her as Diva Domitilla is provided mostly through her representations on the coins issued during the reign of her son, Titus.