Lucius Domitius Alexander (died c. 310), probably born in Phrygia, was vicarius of Africa when Emperor Maxentius ordered him to send his son as hostage to Rome.

Maxentius ordered Domitius Alexander, the vicar of Africa, to send his son to Rome to secure his loyalty.

[2] Apart from the provinces in north Africa (today's Algeria, Tunisia and western Libya), Domitius Alexander also controlled Sardinia.

There is evidence in an inscription (CIL viii, 22183) that Alexander and Constantine I allied themselves in opposition to Maxentius.

[3] Maxentius sent his praetorian prefect Rufius Volusianus and a certain Zenas to quell the rebellion, and Alexander was taken prisoner and then executed by strangulation.