"Don't Mess with My Man" is a song by American R&B singer Nivea featuring Brian and Brandon Casey from R&B group Jagged Edge.

The song peaked at number eight on the Billboard Hot 100 and was an international hit as well, reaching the top 10 in France and New Zealand and receiving a gold certification in the former country.

The recording earned the artists a nomination for Best R&B Performance by a Duo or Group with Vocals at the 45th Grammy Awards in 2003.

[1] Nzingha Stewart directed a music video for an alternate version of the song, which premiered in June 2002.

The video's background singers featured clothing from Hendricks Apparel Group's Raw Jean collection.