Started in 1948, Don Bosco is one of the leading private schools in the North-Eastern states.

The name Our Lady’s Orphanage was then changed to Don Bosco Technical School, Guwahati.

In February 1948, at an inaugural ceremony presided over by Dr. Bhubaneswar Barua, the school was restarted with an enrollment of 92 students in five classes from III to VII.

Public demand in 1958 led to the beginning of the English section from Class VIII with required permission from the University.

It was the first school in the North-East to have computer education (which began in 1987), an auditorium and sports complex (1993), and a meteorological observatory center (2002).

The teachers of the primary school underwent workshops to familiarize them with child centered and activity oriented teaching methods.

Further the school sought and obtained affiliation under the central Board of Secondary Education.

The first batch of female students in the youngest grades of Kindergarten and Class I were admitted in 2010 and Don Bosco is a co-ed school now.