Don Khon (Lao: ດອນຄອນ), is an island in the Mekong River in the Si Phan Don ("Four Thousand Islands") archipelago in Champasak Province of southern Laos.

[1] The Don Det–Don Khon railway was a 7-kilometer (4.3 mi)-long narrow-gauge portage railway on the islands of Don Khon and Don Det, opened in 1893 to transport vessels, freight, and passengers along the Mekong River, and closed since the 1940s.

There are two Buddhist temples, a primary school and a college on the island.

Don Khon features a tropical wet and dry climate.

While the city is generally very warm throughout the year, it is noticeably cooler during December and January.