Donatien de Bruyne (1871–1935) was a Belgian biblical scholar, textual critic.
He was born on 7 October 1871 in Nieuwkerke (Belgian province of West Flanders), ordained in 1895.
De Bruyne examined and collated hundreds of Latin medieval manuscripts of the Vulgate and ancient biblical exegesis (e.g. Codex Frisingensis, Codex Carinthianus) in the context of the preparation of the critical edition of the Vulgate.
De Bruyne questioned Jerome's authorship of the Pauline epistles of Vulgate.
De Bruyne discovered and published in 1930 an anti-Marcionist Prologue to the Gospel of John.