He was a Big East All-Conference player in 1995 and 1996, and also lettered in indoor and outdoor hurdles, graduating in 1997 with a degree in exercise science and a minor in coaching.

Darius was selected in the first round with the 25th overall pickin the 1998 NFL draft by the Jacksonville Jaguars, then the highest pick ever by the team for a defensive back.

In 2004, Darius led the secondary in tackles for a seventh straight season and posted career highs in forced fumbles and interceptions.

In 2004, Darius was ejected and fined $75,000 for an illegal clothesline tackle on Green Bay Packers wide receiver Robert Ferguson.

He was subsequently transported to a Jacksonville area hospital for a mental health evaluation after telling rescue workers he had ingested 20 to 30 pills and that he was suicidal.