He was selected by the Tennessee Titans in the second round of the 2015 NFL draft and played college football for the Missouri Tigers until he was dismissed from the team in 2014.

[2] A native of Springfield, Missouri, he attended Hillcrest High School, where he was a three-sport star in football, basketball, and track.

[15] He picked Missouri over Southeastern Conference (SEC)-rival Arkansas, also because offensive coordinator Garrick McGee, who had formed a strong relationship with Green-Beckham and his family, left the school in December 2011.

[17] He appeared in the first five games of the season, registering five catches for 125 yards, including an 80-yard touchdown reception against Central Florida.

[18] Then came an arrest and suspension due to drug possession, causing Green-Beckham to miss the Vanderbilt and Alabama game on October 6 and 13, respectively.

Green-Beckham returned for the second half of the season on October 27 against Kentucky, catching a season-high seven throws for 25 yards.

In the final minute of regulation, he caught a game-tying touchdown in the left corner of the end zone.

His 27-yard catch set up Henry Josey's go-ahead score in the Cotton Bowl victory over Oklahoma State.

Green-Beckham attempted to post a waiver request in order to make him eligible to play for the year, but NCAA declined it.

During his time at Oklahoma, he spent his season on the scout team and didn't play a single down for the Sooners before declaring for the draft.

The next game he made his first career catch on a 13-yard touchdown pass from Marcus Mariota in a 28–14 loss at the Cleveland Browns.

He never knew his biological father, and lived in several foster homes before John Beckham, his high school coach, and his wife, Tracy, officially adopted him on December 30, 2009.

[35] According to the Springfield News-Leader, Green-Beckham was originally arrested for possession of a controlled substance with intent to distribute following a traffic stop but was later released without charges, pending further investigation.

[37] On April 11, 2014, Green-Beckham was dismissed from the University of Missouri football team, following his prior drug-related problems and an incident in which he allegedly forced open an apartment door and pushed a woman down a flight of stairs.

Head coach Gary Pinkel said in a prepared statement, "This decision was made with the best interests of all involved in mind.