Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma.

[6][7] Dorzolamide is used to lower excessive intraocular pressure in open-angle glaucoma and ocular hypertension.

The H+ is then exchanged for sodium (Na+) ions, which facilitates the production of aqueous humor [citation needed].

By blocking the function of carbonic anhydrase, the Na+/H+ exchange is unable to occur, which leads to a decrease in Na+ in the cell and prevents aqueous humor production [citation needed].

Dorzolamide, developed by Merck, was the first medication in human therapy (market introduction 1995) that resulted from structure-based drug design.