Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor.
Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.
This drug has displayed teratogenic effects in rats.
Compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.
Recently, research has also uncovered a potential new role for this drug, addressing tau toxicity, a theorized cause for diseases such as Alzheimer’s.