On 15 March 2018, Khamdamov was registered by Russian Premier League club Anzhi Makhachkala, taking the #7 jersey after signing an 18-month contract.

[1][7] On 15 February 2019, Anzhi Makhachkala announced that Khamdamov had left the club to join Pakhtakor Tashkent.

For this performance, he became the first Uzbek player to be nominated as the Asian Young Footballer of the Year.

[12][13] He participated in the 2016 AFC U-23 Championship and scored two goals, but his team went out from the group stage.

For this successful display, Khamdamov earned a place and would go to be part of the senior squad for the 2019 AFC Asian Cup.