[1][2] Born in Namangan Province, Akhmedov began playing football in reserve side of Pakhtakor Tashkent.

[3] He made his official debut for the first-team of Pakhtakor on 16 May 2006 aged 18, in an Uzbek League away match against Qizilqum Zarafshon.

It was revealed by Pakhtakor that Odil Ahmedov had received offers from foreign clubs such as the Russian Premier League members Krylia Sovetov Samara and FC Dynamo Moscow.

But Pakhtakor officials believed that Odil Ahmedov deserves a better offer referring to the top European clubs such as the ones from England, Spain, Germany, Italy, and France.

[8] He made his official debut in Russia in 2010–11 Russian Cup Round of 16 match against Zenit Saint Petersburg on 1 March 2011.

The winner was determined with the survey conducted among official website visitors and finally by club managers and coaches.

Prior to Anzhi suffering relegation, Ahmedov joined Krasnodar in early June 2014, along with teammates Nikita Burmistrov and Vladimir Bystrov.

On 3 July 2014 he scored his second goal on his second appearance for FC Krasnodar to equalize against Scottish football giants Celtic F.C., due to an awful defending error they made.

[12] Ahmedov scored his first official goal for Krasnodar on 1 August 2014 in 2014–15 UEFA Europa League third qualifying round match against Hungarian outfit Diosgyori VTK.

[15] Ahmedov was named Best Player of FC Krasnodar in 2014–15 season on 9 June 2015 after survey conducted on club official website.

[18] He made his official debut on 7 February 2017 in a 3–0 win over Thai club Sukhothai in the 2017 AFC Champions League qualifying play-off.