[7] Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis.

These domains are found in the N terminus of proteins and consists of tandemly repeated copies of an around 80 amino acids region.

It has been suggested that the first DC domain of Doublecortin binds tubulin and enhances microtubule polymerisation.

[12] Doublecortin is mutated in X-linked lissencephaly and the double cortex syndrome, and the clinical manifestations are sex-linked.

Double cortex syndrome is characterized by abnormal migration of neural tissue during development which results in two bands of misplaced neurons within the subcortical white, generating two cortices, giving the name to the syndrome; this finding generally occurs in females.