Doxapram

Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant, or analeptic.

It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as opioids which may fail to respond adequately to treatment with naloxone.

[2] Doxapram has been used as a reversal agent after general anesthesia in captive sharks and rays, but it must be used with caution, as the animals can become excitatory as a side effect.

[3] Side effects include high blood pressure, anxiety, rapid heart rate, tremor, sweating, and vomiting.

It is also contraindicated in newborns and small children, mainly due to the presence of benzyl alcohol, which is included as a preservative.

photograph of a vial of doxapram
A vial of doxapram