[5] It also has antiemetic[6] and pro-respiratory effects, both reducing sleep apnea[7] and reversing opioid-induced respiratory depression in animal studies.

[8] Early animal trials have also revealed that administration of zacopride can reduce preference for and consumption of ethanol.

[9] Zacopride was found to significantly increase aldosterone levels in human subjects for 180 minutes at a dose of 400 micrograms.

Zacopride also stimulated aldosterone secretion when applied to human adrenal glands in vitro.

[2] Zacopride has been tested in clinical trials for the treatment of schizophrenia, but was found unsuccessful.