It was released in 1998 through Ruffhouse/Columbia Records as the second single off of the group's fourth studio album IV.

The Spanish version of the song retitled as ""Dr. Dedoverde" appeared in Los grandes éxitos en español.

In the song B-Real introduces his alter-ego Dr. Greenthumb, a cannabis grower, telling the story from his perspective.

It begins with a comical skit starring the titular salesman who speaks in an unusually high voice.

A farmer named Jed is one of his clients and he explains how Dr. Greenthumb saved his life as he was harassed by the cops because of his marijuana farm.